CERN Accelerating science

MEDICIS Internal Notes

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2018-07-23
00:11
Towards simultaneous MRI-SPECT (gamma-MRI) using highly-polarized gamma-emitting nuclei / Kowalska, Magdalena (CERN)
PET (Positron Emission Tomography), SPECT (Single Photon Emission Computed Tomography), and MRI (Magnetic Resonance Imaging) are indispensable diagnostic approaches in medicine, which exhibit very complementary features. The first two techniques profit from high sensitivity of detecting particles or gamma rays but with lower spatial resolution. [...]
MED-013.- Geneva : CERN, 2018 Fulltext: DOC;

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2018-07-23
00:05
Large production of Scandium and Terbium at very high specific activity for theranostics applications: combining cyclotron production with off-line mass separation / Formento Cavaier, Roberto (Centre National de la Recherche Scientifique (FR))
The new facility CERN-MEDICIS will produce isotopes using the CERN proton beam at 1.4 GeV coming from the CERN Proton Booster. However, during short and long shutdowns the direct production of radionuclides at MEDICIS cannot be possible [...]
MED-012.- Geneva : CERN, 2018 - 3. Fulltext: DOC;

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2018-07-22
23:58
Very high specific activity Er-169 production at MEDICIS from external ILL target / Formento Cavaier, Roberto (Centre National de la Recherche Scientifique (FR))
The new facility CERN-MEDICIS will produce isotopes using the CERN proton beam at 1.4 GeV coming from the CERN Proton Booster. However during short and long shutdowns the direct production of radionuclides at MEDICIS cannot be possible [...]
MED-011.- Geneva : CERN, 2018 - 2. Fulltext: DOC;

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2018-07-22
23:52
Laser ionization yield enhancement of external targets radionuclides production at CERN-MEDICIS / Formento Cavaier, Roberto (Centre National de la Recherche Scientifique (FR))
The new facility CERN-MEDICIS will produce dedicated radioisotopes for medical applications using the CERN proton beam of 1.4 GeV coming from the CERN Proton Booster. However, during short and longer shutdowns of the CERN accelerator facilities the direct production of radionuclides at MEDICIS cannot be possible. [...]
MED-010.- Geneva : CERN, 2018 - 3. Fulltext: DOC;

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2018-07-22
23:41
Study of lung tumours by using theragnostics with radioactive isotopes of Terbium
In recent years, a number of nuclear-medicine techniques developed for cancer therapy are based on the use of two different radioactive isotopes of the same chemical element, one for diagnosis and the other for therapy; this is the so called theragnostics technique. The diagnostic’s radioisotope will provide the location of the tumour and will decay by gamma emission with a short half-life (hours), whereas the therapeutic radioisotope will attack the tumour by beta/alpha emission having usually a longer half-life (days). [...]
MED-009.- Geneva : CERN, 2018 - 2. Fulltext: DOCX;

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2018-07-22
23:26
Development of CXCR4-targeted agents for molecular radiotherapy with 67Cu
CXCR4 is overexpressed in a wide range of malignancies, and agents for the detection and endoradiotherapeutic ablation of this target are entering clinical practice based on the peptide Pentixafor and the isotope pair 68Ga/177Lu. Disadvantages have been demonstrated due to the structural variation on using the different radiometals. [...]
MED-008.- Geneva : CERN, 2018 - 2. Fulltext: DOC;

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2018-07-22
23:17
Carbon release study from BN / Stegemann, Simon Thomas (KU Leuven (BE))
Hadron therapy, in par􏰀cular carbon therapy is a very precise treatment for localized cancers where the tumor is irradiated by a pure and intense carbon beam. Such a treatment reduces the dose delivery to healthy 􏰀ssue due to the very localized energy deposi􏰀on at the end of the beam trajectory (Bragg-peak). [...]
MED-007.- Geneva : CERN, 2018 - 4. Fulltext: PDF;

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2018-07-22
23:10
MEDICIS-Promed Contest / Cocolios, Thomas Elias (KU Leuven (BE))
MEDICIS-Promed [MEDICIS-Promed] is a Marie Skłodowska Curie Action, Innovative Training Network, supported by the European Commission. It supports 15 Early Stage Researchers (ESR), most of whom are also registered in doctoral schools. [...]
MED-006.- Geneva : CERN, 2018 - 2. Fulltext: DOC;

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2018-07-22
22:59
155/161Tb-labeled peptides towards the estrogen receptor for breast cancer theranostics
Breast cancer (BC) remains the most common invasive cancer diagnosed among women and the second most frequent cause of cancer-related death in women worldwide. Although most BC cases are hormone-responsive, BC is a highly heterogeneous disease with distinct prognosis [...]
MED-005.- Geneva : CERN, 2018 - 3. Fulltext: DOC;

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2018-07-22
22:28
Clickable Terbium Complexes for Radioimmuno-Imaging & Therapy
Terbium is an excellent candidate for theranostic applications possessing different clinically relevant radioisotopes for imaging and therapy. Most importantly, the identical chemical properties of these radioisotopes permit the synthesis of radioconjugates having strictly the same pharmacokinetics, to be used for PET (e.g [...]
MED-004.- Geneva : CERN, 2018 - 3. Fulltext: DOC;

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